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US EPA to improve endocrine screening

The US EPA aims to make greater use of computational and high-throughput (HTP) screening methods with a view to increasing the efficiency of its endocrine disruptor screening programme (EDSP) for pesticides and other chemicals. The long-term goal is to replace in vivo screening assays with in vitro HTP assays and eliminate the use of animals for screening purposes. These aims were laid down in the EPA’s EDSP21 Work Plan, which was issued in December. It is based on recommendations in a 2007 National Research Council report on toxicity testing in the 21st century.

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